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Updated: Jul 29, 2026

A Method to Study the Impact of Chemically-induced Ovarian Failure on Exercise Capacity and Cardiac Adaptation in Mice
Published on: April 7, 2014
Estrogens, homocysteine, vasodilatation and menopause: basic mechanisms, interactions and clinical implications
R G V Smolders1, M J van der Mooren, P Sipkema
1Project Aging Women, Institute for Cardiovascular Research, Vrije Universiteit, VU University Medical Center, 1007 MB Amsterdam, The Netherlands.
Abstract:
Estrogens influence the independent cardiovascular risk factor homocysteine as well as vasodilatation. Homocysteine alone also influences vasodilatation, indicating a relational triangle that seems important in interpreting the isolated effects of estrogens on homocysteine metabolism and vasoreactivity. This paper gives an overview of the current understanding regarding vasoreactivity, homocysteine metabolism and the role of estrogens. This is placed against the background of the clinical trials on the effect of postmenopausal hormone replacement therapy on homocysteine levels and addresses the importance of the interaction between homocysteine, estrogens and vasoreactivity.
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