Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bone quality: where do we go from here?

Mary L Bouxsein

    Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
    |September 25, 2003
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Intermittent parathyroid hormone employs autonomous and non-autonomous mechanisms to drive osteogenesis from Ebf3-expressing skeletal progenitor cells.

    bioRxiv : the preprint server for biology·2026
    Same author

    Inflammation and alterations in redox homeostasis precede and persist following musculoskeletal injury in US army trainees.

    British journal of sports medicine·2026
    Same author

    Artificial gravity during spaceflight prevents gait and performance deficits in a gravity-dose dependent manner.

    Life sciences in space research·2026
    Same author

    Monte Carlo Resampling Validates Use of Bone Mineral Density Change as Surrogate to Replace Fracture in Future Randomized Trials of Osteoporosis Treatments: Results From SABER.

    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2026
    Same author

    The orally available SIK2/SIK3 inhibitor SK-124 increases bone mass in hypogonadal male mice.

    JBMR plus·2026
    Same author

    Contributions of Bone Microarchitecture to Skeletal Fragility in Adults with Longstanding Type 1 Diabetes.

    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2026
    Same journal

    Author response to the letter to the editor regarding "Hip Response to Romosozumab in Glucocorticoid Users: Beyond Systemic Bone Turnover Markers".

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2026
    Same journal

    Preventing post-denosumab bone loss with zoledronate: a 2-year randomized trial in post-menopausal women without and with pre-exposure to bisphosphonates.

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2026
    Same journal

    Revisiting the Osteoporosis Self-Assessment Tool (OST): evidence from a multi-cohort study in Asia supporting age-dependent thresholds.

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2026
    Same journal

    Multimorbidity patterns among fragility fracture patients aged 50 + years in China and the US.

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2026
    Same journal

    Parkinson's disease severity and treatment classification in interpreting bisphosphonate-associated fracture risk.

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2026
    Same journal

    Hip response to romosozumab in glucocorticoid users: beyond systemic bone turnover markers.

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2026
    See all related articles

    Understanding bone quality is crucial for addressing skeletal fragility in aging and disease. Future research aims to identify fracture resistance factors for better treatments and diagnostics.

    Area of Science:

    • Biomedical Engineering
    • Skeletal Biology
    • Gerontology

    Background:

    • Bone quality research is a growing field driven by the need to understand skeletal fragility.
    • Aging and diseases increase fracture risk, necessitating a deeper understanding of bone's resistance mechanisms.
    • Past decade collaborations yielded insights into biological, material, and structural contributors to fragility.

    Purpose of the Study:

    • To integrate current literature and meeting discussions on bone quality.
    • To highlight consensus and controversial areas in bone fragility research.
    • To identify critical future research directions for improving bone health.

    Main Methods:

    • Literature review and synthesis of scientific meeting presentations and discussions.

    Related Experiment Videos

  • Analysis of interdisciplinary collaborations involving biologists, physicists, engineers, and clinicians.
  • Identification of key features contributing to skeletal fragility.

    • Main Results:

    • Significant progress has been made in understanding bone's biological, material, and structural properties.
    • Despite advancements, critical knowledge gaps remain in fully defining bone's fracture resistance.
    • Interdisciplinary approaches have spurred new insights but also revealed ongoing debates.

    Conclusions:

    • Further research is essential to comprehensively define bone quality and its determinants.
    • Developing novel biomarkers and noninvasive imaging modalities is a key future goal.
    • Identifying new therapeutic targets for skeletal fragility requires a complete understanding of fracture resistance.