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Synthesis of oligosaccharides on soluble high-molecular-weight branched polymers in combination with purification by

Debatosh Majumdar1, Tong Zhu, Geert-Jan Boons

  • 1Complex Carbohydrate Research Center, The University of Georgia, 220 Riverbend Road, Athens, Georgia, 30602-4712, USA.

Organic Letters
|September 26, 2003
PubMed

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Oligosaccharide Assembly01:24

Oligosaccharide Assembly

Protein glycosylation starts in the ER lumen and continues in the Golgi apparatus. Glycosyltransferases catalyze the addition of sugar molecules or glycosylation of proteins. Usually, these enzymes add sugars to the hydroxyl groups of selected serine or threonine residues to form O-linked glycans or the amino groups of asparagine residues to form N-linked glycans. Different positions on the same polypeptide chain can contain differently linked glycans.
Multiple sugar molecules that may or may...