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Updated: Aug 31, 2026

Examining Proteasome Assembly with Recombinant Archaeal Proteasomes and Nondenaturing PAGE: The Case for a Combined Approach
Published on: December 17, 2016
The COP9 signalosome: an alternative lid for the 26S proteasome?
1Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520-8104, USA.
Abstract:
Two groups have recently reported ubiquitin-deconjugating activities associated with the COP9 signalosome (CSN). Together with a previously identified deneddylation activity, CSN now appears to possess biochemical activities towards the cullin-containing ubiquitin ligases (e.g. deneddylation) and ubiquitinated protein substrates in the proteasome-mediated degradation processes (e.g. deubiquitination). Here, we discuss how these findings support a central role for CSN in ubiquitination of substrate proteins and their proteolysis
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