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Updated: Aug 31, 2026

Merging Ion Concentration Polarization between Juxtaposed Ion Exchange Membranes to Block the Propagation of the Polarization Zone
Published on: February 23, 2017
Polarizing without a c(l)ue
Marc Sohrmann1, Matthias Peter
1Swiss Federal Institute of Technology (ETH) Zurich, Institute of Biochemistry, HPM G 10, ETH-Hoenggerberg, CH-8093 Zurich, Switzerland. marc.sohrmann@bc.biol.ethz.ch
Abstract:
Most cells polarize in response to an asymmetric signal but some can spontaneously establish a discrete axis of polarity in the absence of a directional cue. Many mathematical models predict that locally acting positive feedback loops and globally acting negative regulators are required for pattern formation. Here, we summarize recent progress towards identifying some of the molecular components involved in these positive and negative feedback mechanisms. In addition, we describe the increasing evidence suggesting that the actin cytoskeleton is fundamentally important for the spontaneous symmetry breaking observed in a range of different organisms.
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