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Related Experiment Videos

Injection therapy of superficial rheumatoid nodules.

D W Ching1, J P Petrie, P Klemp

  • 1Queen Elizabeth Hospital for Rheumatic Disease and Rehabilitation, Rotorua, New Zealand.

British Journal of Rheumatology
|November 1, 1992
PubMed
Summary

Intralesional corticosteroid injections effectively treat rheumatoid nodules. A study found methylprednisolone injections significantly reduced nodule size and volume compared to placebo, with minimal side effects.

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Area of Science:

  • Rheumatology
  • Dermatology
  • Pharmacology

Background:

  • Intralesional corticosteroid injection for rheumatoid nodules, though described in 1968, is underutilized.
  • Rheumatoid nodules are common subcutaneous manifestations of rheumatoid arthritis.

Purpose of the Study:

  • To evaluate the efficacy and safety of intralesional corticosteroid injections for rheumatoid nodules.
  • To compare methylprednisolone and lignocaine injections against a placebo of lignocaine alone.

Main Methods:

  • A placebo-controlled, double-blind trial involving 24 rheumatoid nodules from 11 patients.
  • Assessments included patient and investigator evaluations of nodule size change and gross volume measurements.

Main Results:

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  • Methylprednisolone injections led to significant nodule regression compared to placebo (P < 0.001 for all assessments).
  • Nine of 12 active injections achieved ≥50% volume loss, with two nodules disappearing completely.
  • Patients found active injections more worthwhile than placebo injections.

    • Conclusions:

    • Intralesional corticosteroid injection is an effective and safe treatment for rheumatoid nodules.
    • The procedure offers significant therapeutic benefits with pain during injection as the primary complication.