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Related Experiment Videos

Defining normal left ventricular wall motion from contrast ventriculograms.

Florence H Sheehan1, Edward L Bolson

  • 1Cardiovascular Research and Training Center, University of Washington, Seattle, WA 98195-6422, USA. sheehan@u.washington.edu

Physiological Measurement
|September 26, 2003
PubMed
Summary
This summary is machine-generated.

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Defining normal left ventricular (LV) wall motion is complex due to variability. This study found that factors like institution and patient characteristics influence LV motion, necessitating larger sample sizes for reliable normal range definitions.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Biostatistics

Background:

  • Accurate definition of normal left ventricular (LV) motion is crucial for diagnosing cardiac abnormalities.
  • Existing methods for establishing normal ranges may not fully account for inter-patient and inter-institutional variability.
  • Contrast ventriculography is a standard technique for assessing LV function.

Purpose of the Study:

  • To assess sources of variability in defining the normal range for left ventricular (LV) wall motion.
  • To evaluate the influence of various factors on LV motion measurements.
  • To determine the optimal sample size for establishing reliable normal ranges for LV wall motion.

Main Methods:

  • Analysis of contrast ventriculograms from 183 normal patients across six international sites.

Related Experiment Videos

  • Measurement of LV wall motion using the centreline method at seven LV regions.
  • Univariate and multivariate regression analyses to assess the influence of institution, heart rate, age, end-diastolic volume, body surface area, and gender.

    • Main Results:

    • Significant but weak correlations (r < 0.32) were observed between LV wall motion and site, gender, and body surface area in specific regions.
    • Intra-site variability in wall motion measurements was greater than inter-site variability.
    • LV wall motion showed the highest similarity between the two sites with the largest patient cohorts.

    Conclusions:

    • Normal LV wall motion is influenced by multiple patient and institutional factors.
    • Establishing a reliable normal range necessitates analyzing a larger patient cohort (closer to 50 subjects) than commonly referenced (10-20 subjects).
    • These findings highlight the need for standardized protocols and larger datasets in defining normal cardiac function parameters.