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The use of virologically compromised organs in liver transplantation

Hector Rodriguez-Luna1, Juan Arenas, Hugo E Vargas

  • 1Mayo Clinic Scottsdale, Mayo Clinic Hospital, 5777 E. Mayo Boulevard, Phoenix, AZ 85054, USA.

Clinics in Liver Disease
|September 26, 2003
PubMed

Insights

The organ donor shortage allows using organs from hepatitis C (HCV) and hepatitis B (HBV) infected donors. Careful use of anti-HBc positive grafts and HCV+ donor organs in HCV+ recipients expands donor options.

Area of Science:

  • Transplantation immunology
  • Infectious disease transmission in organ donation
  • Hepatitis virus epidemiology

Background:

  • Critical organ donor shortage necessitates innovative solutions.
  • Increasing acceptance of organs from donors infected with hepatitis C virus (HCV) and hepatitis B virus (HBV).
  • These organs, while posing transmission risks, can expand the donor pool.

Purpose of the Study:

  • To evaluate the safety and efficacy of using organs from donors infected with HCV and HBV.
  • To assess the outcomes of using anti-HBc positive grafts with prophylaxis.
  • To determine the viability of using HCV+ donor organs in HCV+ recipients.

Main Methods:

  • Review of current practices in organ transplantation from infected donors.
  • Analysis of outcomes data for recipients of anti-HBc positive grafts.
  • Evaluation of clinical results for HCV+ donor organs transplanted into HCV+ recipients.

Main Results:

  • Anti-HBc positive grafts can be safely utilized with appropriate prophylactic measures.
  • High-quality organs from HCV+ donors demonstrate good outcomes when transplanted into HCV+ recipients.
  • Utilizing these donor organs expands opportunities for patients awaiting transplantation.

Conclusions:

  • Organs from donors infected with HCV and HBV represent a valuable resource to address the organ donor crisis.
  • Careful management and recipient selection allow for successful transplantation of these organs.
  • This approach broadens the donor pool and offers life-saving opportunities.

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