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Synthesis and hypnotic-sedative activities of N-substituted uracil on mice
Tokumi Maruyama1, Shigetada Kozai, Tomomi Shimizu
1School of Pharmaceutical Sciences, Kyushu University of Health and Welfare, 1714-1 Yoshino-cho, Nobeoka 882-8508, Japan.
Nucleic Acids Research. Supplement (2001)
|September 27, 2003
Abstract:
N3-Phenacyl-N1-substituted uracils 3a-q were synthesized by introduction of substituents at the N1-position of N3-phenacyluracil 2, and their hypnotic and sedative activities were evaluated. Pharmacological activities of these N3-phenacyl-N1-substituted uracils were examined using hypnotic activity and synergistic effects with pentobarbital or diazepam for the hypnotic and sedative activities.
