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Detection of the C-C mismatched base pair by small ligands
Akio Kobori1, Hitoshi Suda, Kazuhiko Nakatani
1PRESTO, Japan Science and Technology Corporation, Kyoto 606-8501, Japan.
Nucleic Acids Research. Supplement (2001)
|September 27, 2003
Abstract:
We synthesized 2-aminonaphthyridine derivatives that specifically bind to cytosine-cytosine (C-C) mismatch. The binding of ligands was verified by observing an increase of melting temperature for 11-mer duplexes containing a mismatch in the presence of ligands. It was found that the aminonaphthyridine dimer stabilized C-C mismatch more strongly than the monomer.