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Photochemical ligation of DNA "words" for DNA computing
Naoto Kishi1, Masayuki Ogino, Isao Saito
1Faculty of Material Science, JAIST, 1-1, Tatsunokuchi-cho, Ishikawa 923-1292.
Nucleic Acids Research. Supplement (2001)
|September 27, 2003
Abstract:
The photochemical DNA computing of 5-vinyluracil ((V)U) containing oligodeoxynucleotides (ODNs) tethered multiple "DNA words" is demonstrated. A new MARK and UNMARK operation based on the (V)U mediated reversible DNA photoligation has been developed for multiple-word DNA computing. The utility of this operation for DNA computing is demonstrated by solving a small Satisfiability problem (SAT problem) in which information was encoded in three tandem words.