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Related Experiment Videos

Hailey-Hailey disease--exacerbation by herpes simplex virus and patch tests.

T Peppiatt1, M Keefe, J E White

  • 1Department of Dermatology, Royal South Hants Hospital.

Clinical and Experimental Dermatology
|May 1, 1992
PubMed
Summary

Hailey-Hailey disease, a rare genetic blistering condition, can be exacerbated by herpes simplex virus type 1 (HSV). Patch testing in these patients may cause severe blistering, highlighting potential risks.

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Area of Science:

  • Dermatology
  • Genetics
  • Infectious Diseases

Background:

  • Benign familial chronic pemphigus, or Hailey-Hailey disease, is a rare inherited blistering disorder.
  • It typically affects skin areas prone to friction, such as the neck, axillae, and groin.
  • Contact sensitivity to topical treatments is common, leading to routine patch testing recommendations.

Observation:

  • A 43-year-old veterinary surgeon with Hailey-Hailey disease experienced an acute exacerbation.
  • The exacerbation was triggered by herpes simplex virus type 1 (HSV) infection.
  • Patch testing, performed to rule out contact dermatitis, resulted in severe local blistering.

Findings:

  • Herpes simplex virus type 1 (HSV) is a recognized trigger for Hailey-Hailey disease exacerbations.

Related Experiment Videos

  • Patch testing in patients with Hailey-Hailey disease can be hazardous, causing severe blistering.
  • The case highlights the importance of considering viral triggers and the risks associated with diagnostic procedures.

    • Implications:

    • Clinicians should consider HSV as a potential cause of Hailey-Hailey disease flares.
    • Caution is advised during patch testing for patients with Hailey-Hailey disease due to potential for severe reactions.
    • This case underscores the need for careful patient selection and risk assessment before diagnostic interventions.