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Miltefosine (Impavido): the first oral treatment against leishmaniasis
H Sindermann1, S L Croft, K R Engel
1Zentaris AG, Weismüllerstrasse 45, 60314 Frankfurt am Main, Germany.
Medical Microbiology and Immunology
|September 27, 2003
Abstract:
Miltefosine is a novel antileishmanial drug that has significant selectivity in both in vitro and in vivo models. Clinical efficacy was demonstrated for the treatment of visceral leishmaniasis with the advantage of oral administration over the currently recommended antileishmanial drugs that require parenteral administration. Miltefosine produces high cure rates also in patients resistant to the standard antimonial therapy.