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Updated: Aug 30, 2026

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction
Published on: January 29, 2019
Technology evaluation: CC49 humanized radioimmunoconjugates, National Cancer Institute
1Washington National Primate Research Center, Department of Pharmaceutics, University of Washington, 3000 Western Avenue, Seattle, WA 98121, USA. nadeem@bart.rprc.washington.edu
Abstract:
The National Cancer Institute and the University of Alabama are developing radiolabeled humanized versions of the anticarcinoma monoclonal antibody CC49 devoid of the CH2 domain (designated HuCC49 delta CH2). The antibody is currently undergoing phase I trials for the potential treatment of various tumors.
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