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Related Experiment Videos

Ketoconazole-induced neurologic sequelae.

Mordechai Bulkowstein1, Yair Mordish, Deena R Zimmerman

  • 1Clinical Pharmacology and Toxicology Unit, Drug Consultation Center, Assaf Harofeh Medical Center, Zerifin, Sackler School of Medicine, Tel-Aviv University.

Veterinary and Human Toxicology
|September 30, 2003
PubMed
Summary

An elderly patient experienced temporary neurological symptoms like leg paralysis and tremor after taking ketoconazole. These adverse drug reactions resolved spontaneously, highlighting the need for vigilance in older individuals.

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Area of Science:

  • Pharmacology
  • Neurology
  • Geriatrics

Background:

  • Ketoconazole is an antifungal medication.
  • Adverse drug reactions (ADRs) can significantly impact patient health.
  • The elderly population may be more susceptible to drug side effects.

Observation:

  • A 77-year-old male experienced acute onset of extremity weakness, leg paralysis, dysarthria, and tremor.
  • Symptoms appeared approximately one hour after the first-ever ingestion of 200 mg ketoconazole.
  • The patient's neurological complaints resolved spontaneously within 24 hours.

Findings:

  • The patient re-experienced similar symptoms within an hour of taking a second 200 mg dose of ketoconazole days later.
  • Neurological symptoms recurred with the same drug exposure.

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  • Laboratory evaluations and head CT scan results were unremarkable.

    • Implications:

    • This case underscores the potential for ketoconazole to cause transient neurological adverse drug reactions.
    • Close monitoring for unexpected side effects is crucial, especially in elderly patients.
    • Physicians should consider drug-induced neurological events in differential diagnoses for older adults presenting with acute neurological deficits.