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Published on: January 7, 2014
Metoclopramide protection of cholinesterase from paraoxon inhibition
Georg A Petroianu1, Mohd Y Hasan, Melita Kosanovic
1Department of Pharmacology & Therapeutics, UAE University, PO Box 17666 Al-Ain, United Arab Emirates.
Abstract:
This study evaluated the protective effect of the benzamide compound metoclopramide (MCP) against inhibition by paraoxon (POX) as assessed by red blood cell acetylcholinesterase (RBC-AChE) activity. Three groups of 6 rats each were used. All substances were applied ip daily for 5 d, followed by a 2-d rest. The 7-d cycle was repeated 6 times. Group 1 received 100 nM POX, Group 2 received 50 microM MCP. Group 3 received 100 nM POX + 50 microM MCP. Red blood cell acetylcholinesterase measurements were performed at base line and then after each 7-d cycle. Enzyme activities were compared using the Mann-Whitney rank order test. Metoclopramide conferred significant in vivo protection from inhibition of RBC-AChE by POX.
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