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Plasma lipoperoxides: a preliminary reference range.

Simmi Kharb1, Veena Singh Ghalaut

  • 1Department of Biochemistry, Pt. B.D. Sharma PGIMS, Rohtak.

Indian Journal of Medical Sciences
|September 30, 2003
PubMed
Summary
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Serum malonaldehyde (MDA), a marker of lipid peroxidation, was higher in women and older adults. These findings suggest increased lipid peroxidation with aging and highlight sex-based differences in MDA levels.

Area of Science:

  • Biochemistry
  • Clinical Chemistry
  • Gerontology

Background:

  • Lipid peroxidation is a key indicator of oxidative stress.
  • Malonaldehyde (MDA) is a biomarker for lipid peroxidation.
  • Establishing reference values for MDA is crucial for clinical assessment.

Purpose of the Study:

  • To determine reference values for serum MDA.
  • To investigate sex-related differences in serum MDA.
  • To examine age-related variations in serum MDA.

Main Methods:

  • Serum samples were collected from 80 males and 120 females.
  • Malonaldehyde (MDA) levels were quantified using the thiobarbituric acid reaction.
  • Statistical analysis was performed to compare sex and age groups.

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Main Results:

  • Women exhibited significantly higher serum MDA concentrations compared to men (p<0.05).
  • Older subjects demonstrated elevated serum MDA levels compared to younger subjects (p<0.05).
  • A positive correlation between age and MDA levels was observed.

Conclusions:

  • Serum MDA levels show significant differences based on sex and age.
  • Increased lipid peroxidation, as indicated by MDA, is associated with aging.
  • These findings provide valuable reference ranges and highlight demographic influences on oxidative stress markers.