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Angioscopic appearance and histopathology of coronary artery thrombi

Takayoshi Ohba1, Noritake Hata, Yoshiharu Ohaki

  • 1Division of Pathology, Chiba Hokusoh Hospital, Nippon Medical School, Chiba, Japan.

Asian Cardiovascular & Thoracic Annals
|September 30, 2003
PubMed

Insights

This study reports on a 70-year-old woman with acute coronary syndrome. Successful aspiration of red thrombi from the left circumflex artery using RESCUE thrombectomy restored coronary blood flow.

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Thrombosis Research

Background:

  • Acute coronary syndrome (ACS) necessitates prompt restoration of coronary blood flow.
  • Left circumflex artery (LCx) occlusions can present as ACS.
  • Thrombus aspiration is a potential intervention for occlusive coronary events.

Observation:

  • A 70-year-old female patient presented with symptoms of acute coronary syndrome.
  • Coronary angiography revealed a complete occlusion of the left circumflex artery.
  • Coronary angioscopy identified significant red thrombus burden at the site of occlusion.

Findings:

  • The RESCUE thrombectomy catheter successfully aspirated the obstructive thrombi.
  • Restoration of antegrade coronary blood flow was achieved post-thrombectomy.
  • Histological analysis of the aspirated thrombus showed a composition of platelets, erythrocytes, leukocytes (predominantly neutrophils), and endothelial-like tissue.

Implications:

  • Percutaneous coronary intervention with thrombectomy can be effective in managing LCx occlusions presenting as ACS.
  • Understanding thrombus composition may inform treatment strategies for acute myocardial infarction.
  • The RESCUE thrombectomy device demonstrates utility in removing large coronary thrombi.

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