Related Experiment Video
Updated: Aug 21, 2026

Protein Misfolding Cyclic Amplification of Prions
Published on: November 7, 2012
Collapsin response mediator proteins (CRMPs): involvement in nervous system development and adult neurodegenerative
Emmanuelle Charrier1, Sophie Reibel, Véronique Rogemond
1Institut National de la Santé et de la Recherche Médicale U 433, Hôpital Neurologique, 59 Bd Pinel, 69003 Lyon, France.
Abstract:
The members of the collapsin response mediator protein (CRMP) family-five cytosolic phosphoproteins -are highly expressed throughout brain development. The first member to be cloned, CRMP2, was identified as an intracellular messenger required for the growth cone-collapse induced by semaphorin 3A (Sema3A). A rapidly expanding body of study indicates that the functions of CRMPs are not solely limited to the signaling transduction of the Sema3A guidance cue. They are probably involved in multiple cellular and molecular events involved in apoptosis/proliferation, cell migration, and differentiation. In the adult brain, the expression of CRMPs is dramatically downregulated. However, they remain expressed in structures that retain their capacity for differentiation and plasticity and also in a subpopulation of oligodendrocytes (CRMP2 and CRMP5). Moreover, the expression of CRMPs is altered in neurodegenerative diseases, and these proteins may be of key importance in the physiopathology of the adult nervous system.
More Related Videos
07:26High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
Published on: July 18, 2017
10:50Molecular Modulation by Lentivirus-Delivered Specific shRNAs in Endoplasmic Reticulum Stressed Neurons
Published on: April 24, 2021
Related Concept Videos
The Unfolded Protein Response
Regulation of the Unfolded Protein Response
Caspases
MAPK Signaling Cascades
Calmodulin-dependent Signaling
The Ca2+-CaM complex does not have enzymatic activity by itself. Instead, the complex binds downstream target proteins, including membrane proteins or enzymes,...
Role of Matrix Metalloproteases in Degradation of ECM
A...