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Updated: Aug 30, 2026
Preparation Of Neovascular Tissues from Human Glioma Tissues for Quantitative Proteomics Analysis of Tumor Angiogenesis
Published on: March 20, 2026
Current strategies and future directions of antiangiogenic tumor therapy
Zi-Lai Zhang1, Jin-Hui Wang, Xin-Yuan Liu
1Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, the Chinese Academy of Sciences, Shanghai 200031, China.
Abstract:
Neovascularization is a prerequisite for progressive growth of most tumors and their metastases. Therefore, inhibition of angiogenesis could be one of the most promising strategies that might lead to the development of novel anticancer therapy. New blood vessels forming in tumors can be avoided by interfering the process of angiogenesis through suppressing the proangiogenic signal or augmenting the antiangiogenic factors. Concentrated efforts in this area have lead to the discovery of many proangiogenic factors as well as their inhibitors, and antiangiogenic factors. For the established tumor vasculature, tumor vasculature-targeted delivery of antiangiogenic substances and endothelial cell vaccines has been explored. Although some antiangiogenic drugs are currently in clinical development, for future reason, more efficient therapeutic methods, including antiangiogenic gene therapy strategy, targeted drug delivery system, and the combination of antiangiogenic agents with immunotherapy, chemotherapy or radiotherapy are being explored. With the development of tumor model assessment system, clinical use of the above antiangiogenic tumor therapy methods could be achieved.
Insights
Inhibiting tumor angiogenesis, the formation of new blood vessels, is a promising anticancer strategy. Research explores novel methods like gene therapy and drug delivery to enhance anti-angiogenic treatments.
Area of Science:
- Oncology
- Vascular Biology
- Biomedical Research
Background:
- Neovascularization is essential for tumor growth and metastasis.
- Inhibiting angiogenesis offers a promising strategy for novel anticancer therapies.
- Tumor blood vessel formation can be targeted by modulating pro- and anti-angiogenic factors.
Purpose of the Study:
- To review strategies for inhibiting tumor angiogenesis.
- To explore novel therapeutic approaches for anti-angiogenic tumor therapy.
- To discuss the potential of combining anti-angiogenic treatments with other therapies.
Main Methods:
- Review of existing research on angiogenesis inhibitors and proangiogenic factors.
- Exploration of targeted delivery systems for anti-angiogenic substances.
- Investigation of endothelial cell vaccines and anti-angiogenic gene therapy.
Main Results:
- Discovery of numerous proangiogenic factors and their inhibitors.
- Development of targeted delivery methods for anti-angiogenic agents.
- Identification of combination therapies (immunotherapy, chemotherapy, radiotherapy) as promising avenues.
Conclusions:
- Inhibiting tumor angiogenesis is a key strategy in cancer therapy.
- Advanced methods like gene therapy and targeted drug delivery are under investigation.
- Combination therapies and improved assessment systems are crucial for clinical application.
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