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Related Experiment Videos

Macaque monkey retrosplenial cortex: II. Cortical afferents.

Yasushi Kobayashi1, David G Amaral

  • 1Department of Psychiatry, Center for Neuroscience, California National Primate Research Center, and the M.I.N.D. Institute, University of California, Davis, Davis, California 95616, USA.

The Journal of Comparative Neurology
|September 30, 2003
PubMed
Summary

This study maps brain connections in macaque monkeys, revealing the retrosplenial cortex interfaces working memory and long-term memory, while the posterior cingulate cortex is linked to visuospatial functions.

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Area of Science:

  • Neuroscience
  • Primate Brain Anatomy
  • Cortical Connectivity

Background:

  • The retrosplenial cortex (RSC) and posterior cingulate cortex (PCC, area 23) are crucial for memory and spatial navigation.
  • Understanding their cortical afferents is key to elucidating brain function.

Purpose of the Study:

  • To investigate and quantitatively analyze the cortical afferents of the macaque RSC and PCC (area 23).
  • To delineate the specific brain regions projecting to these interconnected cortical areas.

Main Methods:

  • Utilized retrograde tracers (Fast blue and Diamidino yellow) in macaque monkeys.
  • Injected tracers into the RSC and area 23, followed by quantitative analysis of labeled neuron distribution.

Main Results:

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  • RSC injections labeled neurons primarily in PCC (area 23) and area 31 (78%). Significant projections also found from the hippocampal formation, prefrontal cortex (areas 46, 9, 10, 11), and occipital cortex (V2).
  • Area 23 injections labeled neurons mainly in PCC and RSC (67%). Significant projections also observed from prefrontal cortex (areas 9, 46) and posterior parietal cortex (areas 7a, 7m, LIP, DP).
  • Identified distinct projection patterns suggesting functional specialization between RSC and PCC.

Conclusions:

  • The RSC serves as an interface between prefrontal working memory and medial temporal lobe long-term memory.
  • The PCC is potentially more involved in visuospatial functions.
  • These findings provide a detailed map of cortico-cortical connections relevant to memory and spatial cognition.