Related Experiment Video
Updated: Aug 30, 2026

Establishing a Diaphyseal Femur Fracture Model in Mice
Published on: December 9, 2022
On the modelling bone tissue fracture and healing of the bone tissue
Manuel Doblaré1, José Manuel García
1Group of Structures and Material Modelling, Aragón Institute of Engineering Research (I3A), University of Zaragoza, Spain. mdoblare@posta.unizar.es
Abstract:
This paper reviews the available literature on computational modelling in two areas of bone biomechanics: fracture and healing. Bone fracture analysis attempts to predict the failure of musculoskeletal structures by several possible mechanisms under different loading conditions. However, as opposed to structurally inert materials, bone is a living tissue that can repair itself. An exciting new field of research is being developed to better comprehended these mechanisms and the mechanical behaviour of bone tissue. One of the main goals of this work is to demonstrate, after a review of computational models, the main similarities and differences between normal engineering materials and bone tissue from a structural point of view. We also underline the importance of computational simulations in biomechanics due to the difficulty of obtaining experimental or clinical results.
Related Concept Videos
Fractures: Bone Repair
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
Bone Remodeling and Repair
Bone Remodeling
Growth of Cartilage and Bone Tissue
Bone Formation by Endochondral Ossification
Osteoclasts in Bone Remodeling

