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Related Experiment Videos

Diabetes Decreases FDG Accumulation in Primary Lung Cancer.

Tatsuo Torizuka1, Kenneth R. Zasadny, Richard L. Wahl

  • 1Division of Nuclear Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA

Clinical Positron Imaging : Official Journal of the Institute for Clinical P.E.T
|October 1, 2003
PubMed
Summary
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Diabetes impairs 2-[fluorine-18]-fluoro-2-deoxy-D-glucose (FDG) uptake in primary lung tumors. This reduced FDG accumulation in diabetic patients may decrease the sensitivity of positron emission tomography (PET) for lung cancer detection.

Area of Science:

  • Oncology
  • Nuclear Medicine
  • Metabolic Research

Background:

  • Positron Emission Tomography (PET) with 2-[fluorine-18]-fluoro-2-deoxy-D-glucose (FDG) is a key imaging modality for lung cancer.
  • Diabetes mellitus affects glucose metabolism, potentially influencing FDG uptake in tumors.

Purpose of the Study:

  • To compare the kinetics and accumulation of FDG in primary lung cancer between diabetic and non-diabetic patients using PET.
  • To investigate the impact of diabetes on FDG uptake parameters and tumor-to-background ratios.

Main Methods:

  • Dynamic FDG-PET scans were performed on 5 diabetic and 21 non-diabetic patients with untreated primary lung cancers.
  • Standardized uptake value normalized for lean body mass (SUL) was measured in tumor, blood, muscle, and lung.
  • A 3-compartment metabolic model analyzed FDG kinetics in tumors.

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Main Results:

  • Diabetic patients exhibited significantly decreased tumor SUL, tumor/blood, and tumor/muscle SUL ratios compared to non-diabetic patients (P < 0.02).
  • The rate constant for FDG phosphorylation (k3) and influx constant (Ki) were significantly lower in diabetic patients (P < 0.02).
  • A trend towards a decreased tumor/lung SUL ratio was observed in diabetic patients (P = 0.064).

Conclusions:

  • FDG accumulation and tumor targeting are impaired in primary lung cancers of diabetic patients.
  • Diabetes may reduce the diagnostic sensitivity of FDG-PET for detecting lung cancer.