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Published on: July 30, 2015
Dynamic expression and regulation by Fgf8 and Pou2 of the zebrafish LIM-only gene, lmo4
Mary Ellen Lane1, Alexander P Runko, Nicole M Roy
1Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation Street/LRB822, Worcester, MA 01605, USA. melane@rice.edu
Abstract:
We report the expression of zebrafish lmo4 during the first 48 h of development. Like its murine ortholog, lmo4 is expressed in somitic mesoderm, branchial arches, otic vesicles, and limb (pectoral fin) buds. In addition, however, we report zebrafish lmo4 expression in the developing eye, cardiovascular tissue, and the neural plate and telencephalon. We demonstrate that expression in the rostral hindbrain requires acerebellar (ace/fgf8) and spiel ohne grenzen (spg/pou2) activity.
