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Venous thromboembolic disease in childhood
C Heleen van Ommen1, Marjolein Peters
1Department of Pediatric, Hematology Emma Children's Hospital, AMC Amsterdam, The Netherlands. c.h.vanommen@amc.uva.nl
Seminars in Thrombosis and Hemostasis
|October 1, 2003
Summary
Pediatric venous thrombosis is rare but serious, often linked to medical devices and underlying conditions. Early diagnosis and prevention are crucial due to significant long-term complications.
Area of Science:
- Pediatric Medicine
- Hematology
- Vascular Medicine
Background:
- Pediatric venous thrombosis is an uncommon but significant condition in children.
- It is often associated with underlying clinical conditions and congenital prothrombotic disorders.
- Catheter-related thrombi in the upper venous system are most common.
Purpose of the Study:
- To review the current understanding of pediatric venous thromboembolic disease.
- To highlight diagnostic methods and treatment protocols.
- To emphasize the growing importance of prevention strategies.
Main Methods:
- Review of existing pediatric studies and adult guidelines.
- Analysis of diagnostic techniques, primarily ultrasonography.
- Examination of treatment approaches and long-term outcomes.
Main Results:
- Diagnosis is frequently made using noninvasive methods like ultrasonography.
- Treatment relies on adapted adult protocols and limited pediatric data.
- Long-term complications such as mortality, recurrence, and post-thrombotic syndrome are considerable.
Conclusions:
- The incidence of pediatric venous thrombosis is expected to increase.
- Increased use of central venous catheters and improved survival of chronically ill children contribute to this rise.
- Prevention of pediatric venous thrombosis is becoming an increasingly important clinical issue.
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