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Formal synthesis of squalamine from desmosterol
Kazuo Okumura1, Yutaka Nakamura, Seiji Takeuchi
1Niigata University of Pharmacy and Applied Life Sciences, Japan.
Chemical & Pharmaceutical Bulletin
|October 2, 2003
Abstract:
The key intermediate to squalamine, (5alpha,7alpha,24R)-7,24-dihydroxy-cholestan-3-one, was synthesized from the 3-O-acetyl-24R,25-dihydroxy derivative of desmosterol via 10 steps in 16% overall yield and squalamine was also prepared via two further steps in 7.4% total yield from the desmosterol derivative.