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Myrsinoic acid E, an anti-inflammatory compound from Myrsine seguinii
Hidefumi Makabe1, Shintaro Miyazaki, Tsunashi Kamo
1Sciences of Functional Foods, Graduate School of Agriculture, Shinshu University, Kami-ina, Nagano, Japan. makabeh@gipmc.shinshu-u.ac.jp
Abstract:
The methanolic extract of Myrsine seguinii yielded the novel anti-inflammatory compound, myrsinoic acid E (1), whose structure was elucidated to be 3,5-digeranyl-4-hydroxy benzoic acid. We synthesized 1- and its 3,5-diprenyl (2) and 3,5-difarnesyl analogues (3). Compounds 1-3 suppressed 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation of mouse ears by 59%, 14%, and 69% at a dose of 1.4 micromol.

