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Related Experiment Videos

Subthalamic nucleus stimulation affects a frontotemporal network: a PET study.

Ulrike Schroeder1, Andreas Kuehler, Klaus W Lange

  • 1Department of Neurology, Technische Universität München, München, Germany.

Annals of Neurology
|October 2, 2003
PubMed
Summary
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Deep brain stimulation (DBS) for Parkinson's disease can impact verbal fluency. STN stimulation reduced blood flow in brain areas crucial for language tasks, explaining this common side effect.

Area of Science:

  • Neuroscience
  • Neurology
  • Medical Imaging

Background:

  • Deep brain stimulation (DBS) of the subthalamic nucleus (STN) effectively treats motor symptoms in advanced Parkinson's disease (PD).
  • Clinical observations suggest that STN-DBS can negatively affect verbal fluency in PD patients.

Purpose of the Study:

  • To investigate the neurobiological effects of STN-DBS on regional cerebral blood flow during a verbal fluency task in Parkinson's disease patients.
  • To elucidate the neural mechanisms underlying the observed decline in verbal fluency associated with STN-DBS.

Main Methods:

  • Positron emission tomography (PET) was used to measure regional cerebral blood flow.
  • Seven patients with advanced Parkinson's disease and bilateral STN-DBS were assessed during a verbal fluency task in both ON and OFF stimulation states.

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Main Results:

  • STN stimulation led to decreased activation in the right orbitofrontal cortex.
  • A reduction in verbal fluency-associated activation was observed within a left-sided frontotemporal network during STN stimulation compared to the OFF state.

Conclusions:

  • STN-DBS alters brain activity within frontotemporal networks during verbal fluency tasks.
  • These findings provide a neurobiological explanation for the common neuropsychological side effect of impaired verbal fluency following STN-DBS in Parkinson's disease.