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Pharmacotherapy for personality disorders.

Giles Newton-Howes1, Peter Tyrer

  • 1Department of Psychological Medicine, Imperial College London, Charing Cross Campus, St. Dunstan's Road, London, W6 8RP, UK.

Expert Opinion on Pharmacotherapy
|October 3, 2003
PubMed
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Drug treatments show promise for certain personality disorders, especially borderline personality disorder. While antidepressants appear beneficial, evidence for antipsychotics and mood stabilizers is less conclusive, with no specific indications yet established.

Area of Science:

  • Psychiatry
  • Pharmacology
  • Clinical Psychology

Background:

  • Personality disorders present treatment challenges due to methodological uncertainties regarding efficacy.
  • Borderline personality disorder shows the most promising evidence for drug treatment, yet distinguishing mental state from personality components remains difficult.

Purpose of the Study:

  • To review the current evidence for the efficacy of drug treatments in personality disorders.
  • To identify specific drug classes and their potential benefits in managing personality disorder symptoms.

Main Methods:

  • Review of existing literature on pharmacological interventions for personality disorders.
  • Analysis of evidence for antidepressants, antipsychotics, and mood stabilizers.

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Main Results:

  • Antidepressants, particularly serotonin re-uptake inhibitors (SSRIs) and monoamine oxidase inhibitors (MAOIs), demonstrate beneficial effects independent of their antidepressant action.
  • Antipsychotic drugs and mood stabilizers may also offer value, though evidence is less favorable.
  • Evidence for specific drug treatment indications remains insufficient across all personality disorders.

Conclusions:

  • While drug treatments show potential for certain personality disorders like borderline personality disorder, definitive indications are lacking.
  • Further research is needed to clarify the specific roles and efficacy of different drug classes in managing personality disorders.