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[A study on the pathogenicity of Helicobacter pylori in chronic gastritis and peptic ulcer disease]
Abstract:
Gastroendoscopic biopsy specimens from 366 patients were stained with HE, Warthin-Starrys or Giemsa and mucin histochemical methods. Positive rate of Helicobacter pylori (HP) was 73.8% in chronic gastritis. Positive rates of HP in gastric ulcer disease were 88.2%, 91.9%, and 11.1% at the near and distant mucosa of ulcer and in duodenitis, respectively. Positive rates of HP in duodenal ulcer disease were 81.5%, 24.6% and 7.2% at the pyloric-antral area and at the near and distant mucosa of duodenal ulcer, respectively. The number of HP in active inflammation was higher than that in inactive inflammation (P < 0.05). The HP almost lived in the neutral mucin. There was no statistical significant difference between near and distant mucosa of ulcer (P > 0.05). HP might play an important role in the pathogenesis of chronic gastritis, and it might aggravate the peptic ulcer disease.
Insights
Helicobacter pylori (HP) infection is prevalent in chronic gastritis and peptic ulcer disease. HP presence correlates with active inflammation and may worsen these gastrointestinal conditions.
Area of Science:
- Gastroenterology
- Microbiology
- Histopathology
Background:
- Helicobacter pylori (HP) is a significant pathogen in gastrointestinal diseases.
- Understanding HP's prevalence and role in gastritis and peptic ulcers is crucial for effective treatment.
Purpose of the Study:
- To determine the prevalence of HP in patients with chronic gastritis and peptic ulcer disease.
- To investigate the relationship between HP and inflammation severity and its location in the gastric and duodenal mucosa.
Main Methods:
- Analysis of 366 gastroendoscopic biopsy specimens.
- Staining techniques included HE, Warthin-Starry, Giemsa, and mucin histochemistry.
- HP detection rates were calculated for different conditions and locations.
Main Results:
- HP positive rates were 73.8% in chronic gastritis, 88.2%-91.9% in gastric ulcers, and 81.5% in duodenal ulcers.
- Higher HP numbers were observed in active compared to inactive inflammation (P < 0.05).
- HP predominantly inhabited neutral mucin, with no significant difference in prevalence between near and distant ulcer mucosa.
Conclusions:
- HP plays a critical role in the pathogenesis of chronic gastritis.
- HP infection may exacerbate peptic ulcer disease.
- Targeting HP is essential for managing these gastrointestinal conditions.