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[Association between polymorphisms in the gene coding for glutathione S-transferase P1 and chronic obstructive
Dan Xiao1, Chen Wang, Min-jie Du
1Beijing Chaoyang Hospital-Beijing Institute of Respiratory Medicine, Capital University of Medical Science, Beijing 100020, China.
Objective:
To investigate the association between polymorphisms in the gene coding for glutathione S-transferase P1 (GSTP1) and susceptibility to chronic obstructive pulmonary disease (COPD) in a Chinese population.
Methods:
This was a pilot study of the molecular epidemiology in patients with COPD. The research design was a case-control study. Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) were performed to genotype GSTP1 polymorphisms in exon 5 in 100 COPD patients and 100 age and sex matched healthy controls. Logistic regression analysis method was used to calculate the odds ratio (OR) and the 95% confidence interval (CI).
Result:
There was no significant difference in GSTP1 polymorphisms adjusted by age, sex, body mass index and smoking between COPD patients and controls.
Conclusion:
The gene polymorphism for GSTP1 was not associated with susceptibility to COPD in the Chinese population.