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A new technetium-99m labeled isonitrile complex 99mTc-TMCHI as a potential blood pool imaging agent
X Zh Zhang1, X B Wang, J M Zhou
1Department of Chemistry, Beijing Normal University, Beijing 100875, People's Republic of China.
Abstract:
A new isonitrile ligand 3,3,5-trimethyl cyclohexylisonitrile (TMCHI) and its copper salt [Cu(TMCHI)4BF4] were synthesized and characterized by IR and elemental analysis. 99mTc-TMCHI is prepared by direct labeling method with high RCP. In vitro protein binding in albumin, blood retention and biodistribution of 99mTc-TMCHI in mice indicated that it is mainly accumulated and maintained in blood with a high protein binding rate and low washout rate. The target/non-target ratios in mice are excellent and suggest its use as a cardiac blood pool agent.