Related Experiment Videos
Hemostatic profile in septicemic neonates with and without bleeding
Indian Journal of Pediatrics
|July 1, 1992
Summary
Neonatal septicemia frequently causes bleeding and blood clotting abnormalities. Platelet aggregation issues were more pronounced in neonates with bleeding, indicating a specific hemostatic defect in septicemia.
Area of Science:
- Neonatal Medicine
- Hematology
- Infectious Diseases
Background:
- Neonatal septicemia is a serious condition with potential hemostatic complications.
- Bleeding disorders are a known, but not fully understood, manifestation of neonatal infections.
Purpose of the Study:
- To investigate the hemostatic profile in neonates with septicemia.
- To identify specific coagulation and platelet abnormalities associated with bleeding in this population.
Main Methods:
- Studied 25 full-term neonates with blood culture-proven septicemia.
- Performed detailed coagulation tests and platelet function studies.
- Compared hemostatic parameters between neonates with and without bleeding.
Main Results:
- 96% of septic neonates had deranged coagulation tests and platelet studies.
- Bleeding occurred in 36% of the neonates.
- Platelet aggregation with ADP was significantly more impaired in neonates with bleeding.
Conclusions:
- Neonatal septicemia is associated with widespread hemostatic derangements.
- Impaired platelet aggregation, specifically with ADP, may be a key factor contributing to bleeding in septic neonates.