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Published on: August 11, 2015
Angle closure in younger patients
Robert Ritch1, Brian M Chang, Jeffrey M Liebmann
1Department of Ophthalmology, the New York Eye and Ear Infirmary, 310 East 14th Street, New York, NY 10003, USA.
Insights
Angle-closure glaucoma in young adults is rare and often linked to developmental eye issues, not just pupillary block. Early diagnosis and monitoring are crucial for managing this condition.
Area of Science:
- Ophthalmology
- Glaucoma Research
- Pediatric Ophthalmology
Background:
- Angle-closure glaucoma (ACG) is uncommon in individuals under 40.
- Previous reports on ACG in younger populations are limited and often tied to specific conditions.
Purpose of the Study:
- To evaluate the clinical findings and etiologies of angle-closure glaucoma in patients aged 40 years or younger.
- To understand the differences in ACG causes between younger and older individuals.
Main Methods:
- A retrospective case series analysis of patients aged 40 or younger diagnosed with angle closure.
- Data collected included demographics, clinical examination findings, diagnostic imaging (ultrasound biomicroscopy), diagnoses, and treatments.
- Exclusion criteria included prior incisional surgery and proliferative mechanisms causing angle closure.
Main Results:
- Sixty-seven patients (mean age 34.4 years) were included.
- The most frequent diagnoses were plateau iris syndrome (35 patients) and iridociliary cysts (8 patients).
- Other causes included retinopathy of prematurity, uveitis, nanophthalmos, and various syndromes.
Conclusions:
- The causes of angle-closure glaucoma in young individuals primarily stem from structural or developmental ocular anomalies, differing from the typical relative pupillary block seen in older patients.
- Close monitoring for recurrence and potential need for further interventions (laser or surgery) is recommended after initial treatment like laser iridotomy.
Purpose:
Angle-closure glaucoma is rare in children and young adults; only scattered cases associated with specific clinical entities have been reported. We evaluated the findings in patients aged 40 or younger with angle closure in our database.
Design:
Retrospective noncomparative case series.
Participants:
Our database was searched for patients aged 40 years or younger with angle closure. Data recorded included age at initial consultation, age at the time of diagnosis, gender, slit-lamp examination, gonioscopy, ultrasound biomicroscopy (from 1993 onward), clinical diagnosis, and therapy. Patients with prior incisional surgery were excluded, as were patients with anterior chamber proliferative mechanisms leading to angle closure.
Results:
Sixty-seven patients (49 females, 18 males) met entry criteria. Mean age at the time of consultation was 34.4 +/- 9.4 (standard deviation) years (range, 3-68 years). Diagnoses included plateau iris syndrome (35 patients); iridociliary cysts (8 patients); retinopathy of prematurity (7 patients); uveitis (5 patients); isolated nanophthalmos (3 patients); relative pupillary block (2 patients); Weill-Marchesani syndrome (3 patients); and 1 patient each with Marfan syndrome, miotic-induced angle closure, persistent hyperplastic primary vitreous, and idiopathic lens subluxation.
Conclusions:
The etiology of angle closure in young individuals differs from the older population and is typically associated with structural/developmental ocular anomalies rather than relative pupillary block. After laser iridotomy, these eyes should be monitored for recurrent angle closure and the need for additional laser or incisional surgical intervention.
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