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Histoplasma granuloma of the conjunctiva
David L Knox1, Terrence P O'Brien, W Richard Green
1Eye Pathology Laboratory, Wilmer Institute and Department of Pathology, Johns Hopkins Medical Institution, 600 North Wolfe Street, Baltimore, MD 21287-9248, USA.
Purpose:
To describe the clinical and pathologic features of a conjunctival granuloma resulting from Histoplasma capsulatum.
Design:
Clinicopathologic case report.
Methods:
Surgical excision of conjunctival lesion, histopathologic study with special stains, and a fluorescent antibody technique.
Results:
A conjunctiva granuloma was found to contain microorganisms, compatible with H. capsulatum, confirmed by a fluorescent antibody technique. The conjunctiva returned to normal.
Conclusions:
A focal granuloma of the conjunctiva contained H. capsulatum in a patient whose recent symptoms suggested primary infection. The conjunctival lesion was similar to mucocutaneous lesions seen in patients with systemic histoplasmosis.