Related Experiment Video
Updated: Aug 30, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
Nodular melanoma. No longer as simple as ABC
John W Kelly1, Alexander J Chamberlain, Margaret P Staples
1Dermatology Unit, Victorian Melanoma Service, Alfred Hospital, Melbourne, Victoria. kellyderm@bigpond.com
Background:
Malignant melanoma is the fourth most commonly diagnosed malignancy in Australia. Nodular melanoma (NM) comprise less than 15% of all melanoma but account for up to 70% of those thicker than 3 mm.
Objective:
This article describes the clinical features of NM, its prognosis and management.
Discussion:
Nodular melanoma presents very differently from superficial spreading melanoma, and does not meet the 'ABCD' criteria used to alert doctors and patients to the possibility of this diagnosis. Due to their rapidly developing depth of invasion, urgent referral and wide excision are advised.

