Dicer is essential for mouse development
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Dissection of 6.5 dpc Mouse Embryos
Published on: February 25, 2007
Emily Bernstein1, Sang Yong Kim, Michelle A Carmell
1Cold Spring Harbor Laboratory, Watson School of Biological Sciences, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA.
Nature Genetics
|October 7, 2003
Abstract:
To address the biological function of RNA interference (RNAi)-related pathways in mammals, we disrupted the gene Dicer1 in mice. Loss of Dicer1 lead to lethality early in development, with Dicer1-null embryos depleted of stem cells. Coupled with our inability to generate viable Dicer1-null embryonic stem (ES) cells, this suggests a role for Dicer, and, by implication, the RNAi machinery, in maintaining the stem cell population during early mouse development.
