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[Studies on antiendotoxin action of total saponins from radix Bupleuri]
Yunhai Liu1, Yongshun Chen, Wei Xi
1Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030.
Objective:
To study antiendotoxin activities of total saponins from Radix Bupleuri.
Method:
The antiendotoxin activities were demonstrated by Limulus Amebocyte Lysate test (LAL test) in vitro, the fever model induced by endotoxin in rabbits and the model induced by LPS in BCG-primed mice.
Results:
Total saponins from Radix Bupleuri still had antiendotoxin effect even when it (50 mg.ml-1) was diluted to 32 times by LAL test in vitro. The fever experiment results showed the average rising temperature of BCS + LPS, group, model group and BCS group was 0.75 degrees C, -0.25 degrees C and -0.37 degrees C respectively. In the experiment of the poison induced by LPS, fatal rate of model group was 90.0%, that of BCS + LPS group was 13.3%, there was a significant difference (P < 0.01).
Conclusion:
The result showed that the total saponins in Bupleuri had the strongest antiendotoxin action.