Recent progress in the design of selectin inhibitors
Siri Ram Chhabra1, Aisyah S Abdul Rahim, Barrie Kellam
1School of Pharmacy, University of Nottingham, University Park, Nottingham NG7 2RD, UK.
Mini Reviews in Medicinal Chemistry
|October 8, 2003
Abstract:
The selectins are a family of cell-adhesion proteins that mediate the early stages of leukocyte recruitment from the blood stream to sites of tissue damage through recognition of the carbohydrate epitope sialyl Lewis(x) (sLe(x)). Current development of small molecule based inhibitors of this process and their clinical potential to address numerous acute and chronic diseases are explored.
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