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Reducing integrins improves the quality of fly life
Catherine N Torgler1, Nicholas H Brown
1Wellcome Trust/Cancer Research UK Institute and Department of Anatomy, University of Cambridge, Cambridge CB2 1QR, UK. cnt20@mole.bio.cam.ac.uk
Science of Aging Knowledge Environment : SAGE KE
|October 10, 2003
Abstract:
Integrins are cell surface receptors that mediate adhesion to the extracellular matrix. In this Perspective, we focus on the recent finding that a decrease in the levels of integrins yields fruit flies that retain youthful mobility as they age and display an increased mean life span. We discuss how the reduction of integrin activity might lead to the observed changes.