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Updated: Aug 30, 2026

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
Published on: September 9, 2012
[Upper mesenteric venous thrombosis revealing familial resistance to activated protein C]
Laurent Grimaud1, Gilles Defuentes, Christian Duvic
1Service d'anesthésie-réanimation, Hôpital du Val de Grâce, Paris. GRIMS@caramail.com
Introduction:
Mesenteric venous thrombosis is a rare disease but potentially severe because of the prognosis of intestinal infarction with high mortality rate (60%).
Observation:
We report the case of a 55 year-old man who presented with an upper mesenteric venous thrombosis related to a familial resistance to C reactive protein through factor V Leiden mutation.
Comments:
The discovery of a mesenteric venous thrombosis requires aetiological research that is usually multifactorial. Among the most frequent genetic coagulation abnormalities observed resistance to C reactive protein due to G202110A prothrombin gene mutation is the most common. Although factor V Leiden mutation is less frequent, it requires anticoagulation therapy for life in the case of the appearance of a thrombosis.
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