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Updated: Aug 30, 2026

Recording Synaptic Plasticity in Acute Hippocampal Slices Maintained in a Small-volume Recycling-, Perfusion-, and Submersion-type Chamber System
Published on: January 1, 2018
Effect of pyroglutamylasparagine amide on plastic characteristics of synaptic transmission in the hippocampus
A N Chepkova1, N A Kapai, N V Doreuli
1Institute of Brain Research, Russian Academy of Medical Sciences, Moscow. chepkova@cc.nifni.ac.ru
Abstract:
Preincubation of rat hippocampal slices with 0.05-0.5 microM pyroglutamylasparagine amide improved characteristics of long-term potentiation of focal responses in the synaptic system of Schaffer collaterals-CA1 field pyramids facilitating LTP development and increasing its amplitude and duration. Presumably, the positive modulation of plastic characteristics of synaptic transmission in the hippocampusis is responsible for facilitation of learning and memory induced by pyroglutamylasparagine.
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