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[Megaesophagus microbiota and carcinogenesis].

Denis Pajecki1, Bruno Zilberstein, Manoel Armando Azevedo dos Santos

  • 1Disciplina de Cirurgia do Aparelho Digestivo, Departamento de Gastroenterologia, Faculdade de Medicina, Universidade de São Paulo, Belo Horizonte, MG, Brasil. pajecki@netpoint.com.br

Arquivos De Gastroenterologia
|October 10, 2003
PubMed
Summary
This summary is machine-generated.

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Patients with chagasic megaesophagus harbor bacteria capable of reducing dietary nitrates to nitrites. This bacterial action in esophageal stasis may contribute to N-nitroso compound formation, a risk factor for esophageal cancer.

Area of Science:

  • Gastroenterology
  • Microbiology
  • Oncology

Context:

  • Chagasic achalasia significantly increases esophageal squamous cell carcinoma risk.
  • Bacterial N-nitroso compound production from dietary nitrates is a potential mechanism.

Purpose:

  • To qualitatively and quantitatively analyze esophageal microbiota in chagasic megaesophagus patients.
  • To identify bacteria capable of nitrate reduction within the esophageal lumen.

Summary:

  • Esophageal samples from 15 chagasic megaesophagus patients were analyzed.
  • High bacterial variability was observed, with aerobic Gram-positive and anaerobic bacteria predominating.
  • Staphylococcus sp., Corynebacterium sp., Peptostreptococcus sp., and Veillonella sp. demonstrated nitrate-reducing capabilities.

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Impact:

  • Confirms the presence of nitrate-reducing bacteria in the megaesophagus.
  • Highlights a potential pathway for N-nitroso compound formation in the esophagus.
  • Provides insights into the elevated esophageal cancer risk in these patients.