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Related Experiment Videos

[Phase 2 clinical study of 99mTc-ECD--a multicenter study].

Y Yonekura1, Y Sasaki, A Kubo

  • 1Department of Brain Pathophysiology, Faculty of Medicine, Kyoto University.

Kaku Igaku. the Japanese Journal of Nuclear Medicine
|September 1, 1992
PubMed
Summary
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A new brain perfusion agent, 99mTc-ECD, demonstrated high safety and effectiveness in a phase 2 study for cerebrovascular diseases. This agent offers valuable diagnostic information for brain function impairment.

Area of Science:

  • Nuclear Medicine
  • Radiopharmaceuticals
  • Neurology

Background:

  • Cerebrovascular diseases and impaired brain function require accurate diagnostic tools.
  • Evaluating novel brain perfusion agents is crucial for improving diagnostic capabilities.

Purpose of the Study:

  • To assess the effectiveness, safety, optimal dose, and imaging timing of the novel brain perfusion agent 99mTc-ECD.
  • To evaluate the clinical utility of 99mTc-ECD in patients with cerebrovascular diseases and brain function impairment.

Main Methods:

  • A multi-center phase 2 clinical study involving 166 patients across 10 institutions in Japan.
  • Administration of 99mTc-ECD followed by SPECT imaging at various time points post-injection.
  • Evaluation of safety, side effects, diagnostic information yield, and image quality.

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Main Results:

  • No safety issues or side effects were observed in any of the 166 cases.
  • Valuable diagnostic information was obtained in 98.3% (160/163) of evaluated cases.
  • Images acquired 60-90 minutes post-injection generally showed better quality; 400-800 MBq was deemed appropriate dosage.

Conclusions:

  • 99mTc-ECD is a safe and highly effective radiopharmaceutical for brain perfusion imaging.
  • The agent provides valuable clinical diagnostic information for cerebrovascular diseases and brain function impairment.
  • Optimal imaging timing is between 60-90 minutes post-injection with a dose of 400-800 MBq.