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Updated: Feb 8, 2026

Author Spotlight: Discovering New Alkaloids in Plants with Advanced Mass Spectrometry Techniques
Published on: March 8, 2024
Two novel alkaloids with a unique fused hexacyclic skeleton from Daphniphyllum subverticillatum
Sheng-Ping Yang1, Jian-Min Yue
1State Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, P. R. China.
Abstract:
Two novel major alkaloids, deoxycalyciphylline B (1) and deoxyisocalyciphylline B (2) with a unique fused hexacyclic skeleton, together with a quite recently reported alkaloid calyciphylline B (3), were isolated from the stem of Daphniphyllum subverticillatum. Their structures were established by spectral methods and chemical evidence, especially 2D NMR techniques. The structure of 1 was further confirmed by a single-crystal X-ray diffraction determination.
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