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[Study of large intestinal microflora in newborns with Hirschsprung disease]
Insights
Hirschsprung's disease in infants is strongly linked to severe gut bacteria imbalance (dysbacteriosis). This dysbacteriosis, particularly at advanced stages, correlates with enterocolitis and life-threatening complications like intestinal perforation.
Area of Science:
- Pediatric Surgery
- Gastroenterology
- Microbiology
Context:
- Hirschsprung's disease is a congenital condition affecting the large intestine.
- Early diagnosis and management are crucial for infant outcomes.
- The role of colonic microflora in Hirschsprung's disease pathogenesis is not fully understood.
Purpose:
- To investigate the relationship between colonic microflora and Hirschsprung's disease in infants.
- To determine the prevalence and stages of dysbacteriosis in affected children.
- To assess the association between dysbacteriosis, enterocolitis, and complications.
Summary:
- A study of 35 infants with Hirschsprung's disease revealed significant colonic dysbacteriosis.
- Dysbacteriosis was observed in 2.9% (Phase 1), 20% (Phase 2), and 77.1% (Phase 3) of patients.
- In acute Hirschsprung's disease, 68.5% presented with Phase 3 dysbacteriosis, leading to enterocolitis, acute ileus, and 8 cases of intestinal perforation.
Impact:
- Highlights the critical role of gut microbiota in Hirschsprung's disease progression.
- Suggests dysbacteriosis as a potential marker for severe disease and complications.
- Informs clinical approaches to managing Hirschsprung's disease, potentially including microbiome-targeted therapies.
Abstract:
In 35 newborns and children at the age under 4 mos with Hirschsprung's disease, colonic microflora was studied. Disbacteriosis at phase 1 was revealed in 1 (2.9%) child, at phase 2--in 7 (20%), at phase 3--in 27 (77.1%). In acute form of Hirschsprung's disease, in 68.5% of cases, disbacteriosis at phase 3 with the signs of enterocolitis causing acute ileus was revealed. Intestinal perforation against background of enterocolitis developed in 8 cases.