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Renal function in patients undergoing cardiopulmonary bypass operations.
V Mazzarella1, M T Gallucci, C Tozzo
1Istituto di Tipizzaazione Tissutale e problemi della dialisi-CNR di L'Aquila, Rome, Italy.
The Journal of Thoracic and Cardiovascular Surgery
|December 1, 1992
Summary
Cardiopulmonary bypass temporarily impairs renal functional reserve after surgery. However, kidney function recovers to preoperative levels within six months, indicating no lasting impact on routine renal parameters.
Area of Science:
- Nephrology
- Cardiovascular Surgery
- Physiology
Background:
- Cardiopulmonary bypass (CPB) is frequently used in cardiac surgery.
- The effects of CPB on renal function, particularly renal functional reserve, require further investigation.
- Understanding these effects is crucial for patient management and outcomes.
Purpose of the Study:
- To evaluate the short- and long-term effects of CPB on renal functional reserve.
- To assess changes in basal glomerular filtration rate (GFR) and renal functional reserve after CPB.
- To determine if CPB-induced renal damage impacts routine renal function parameters.
Main Methods:
- A cohort of 11 adult patients undergoing aorta-coronary bypass with CPB was studied.
- Renal functional reserve tests were performed preoperatively, on postoperative day 9, and at 6 months postoperatively.
- Basal glomerular filtration rate was also monitored at these time points.
Main Results:
- Basal glomerular filtration rate showed no significant changes at 9 days or 6 months postoperatively.
- Renal functional reserve was significantly reduced (absent) at 9 days after CPB.
- Renal functional reserve returned to preoperative levels by 6 months after CPB.
Conclusions:
- CPB likely induces renal damage, although not severe enough to alter standard renal function tests.
- Renal functional reserve is a sensitive indicator of subclinical renal injury following CPB.
- Kidney function, specifically renal functional reserve, demonstrates recovery within six months after CPB.