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Rescue of Recombinant Newcastle Disease Virus from cDNA
Published on: October 11, 2013
Newcastle disease vaccines
1B.L.T. Biological Laboratories Teva, Teva Pharmaceutical Industries Ltd. (Abic Vet.), P.O.B. 27047, Jerusalem, Israel.
Biotechnology Advances
|October 11, 2003
Summary
Newcastle disease (ND) is a global avian disease caused by Newcastle disease virus (NDV). This review discusses NDV strains, their virulence, and the production and use of ND vaccines for disease control.
Area of Science:
- Veterinary Virology
- Avian Pathology
Background:
- Newcastle disease (ND) poses a significant global economic threat to poultry industries.
- Newcastle disease virus (NDV), a Paramyxoviridae member, exhibits variable pathogenicity influenced by environmental factors.
- NDV strains are categorized by virulence: lentogenic (mild, vaccine use), mesogenic (moderate, restricted use), and velogenic (highly virulent, challenge models).
Purpose of the Study:
- To review the classification of Newcastle disease virus (NDV) strains based on virulence.
- To discuss the production and application of Newcastle disease vaccines.
- To provide an overview of NDV vaccine strategies and their implications.
Main Methods:
- Literature review of NDV classification and vaccine development.
- Analysis of NDV strain virulence and pathogenicity.
- Examination of vaccine production methods (live and inactivated).
Main Results:
- Lentogenic NDV strains are suitable for live vaccines in young poultry.
- Mesogenic NDV strains face restrictions due to disease emergence concerns.
- Velogenic NDV strains are primarily used in vaccine challenge tests.
Conclusions:
- Understanding NDV strain virulence is crucial for effective vaccine selection and deployment.
- The production and use of Newcastle disease vaccines are essential for controlling the disease in poultry.
- Ongoing research and regulatory oversight are necessary for safe and effective NDV vaccination programs.
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