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Harnessing machine learning to decode and optimize bioelectrochemical systems: Principles, progress and future
Mingyang Liu1, Tianru Lou2, Yanan Yin3
1Laboratory of Chemistry & New Energy Technol, INET, Tsinghua University, Beijing 100084, PR China.
Biotechnology Advances
|August 8, 2026
Summary
Machine learning (ML) is revolutionizing bioelectrochemical systems (BES) for energy and wastewater treatment. ML enhances understanding and optimization, with artificial neural networks being a key algorithm, despite data limitations.
Area of Science:
- Bioelectrochemical Systems (BES)
- Machine Learning (ML)
- Environmental Engineering
- Renewable Energy
Background:
- Bioelectrochemical systems (BES) integrate multiple engineering disciplines for energy generation and wastewater treatment.
- The complexity of BES hinders understanding and optimization, necessitating advanced analytical approaches.
- Machine learning (ML) offers powerful tools for pattern recognition and modeling of complex systems like BES.
Purpose of the Study:
- To systematically review the application of ML in BES.
- To identify key application domains, prevalent ML algorithms, and BES subtypes utilizing ML.
- To highlight challenges and future directions for ML deployment in BES research.
Main Methods:
- Systematic literature review of ML applications in BES from 2006 to present.
- Categorization of ML applications into four main domains.
- Analysis of ML algorithm popularity and BES subtype prevalence.
Main Results:
- ML applications in BES surged around 2021, indicating growing research interest.
- Dominant applications include performance prediction and optimization, followed by microbial community analysis, intelligent design, and control.
- Microbial fuel cells (42.4%) and electrochemical biosensors (37.6%) are the most studied BES subtypes using ML.
- Artificial neural networks (30.9%) are the most common ML algorithms, followed by support vector machines (17.3%).
Conclusions:
- ML shows significant potential to advance BES design, operation, and application.
- Current ML models face limitations in transferability due to data scarcity and heterogeneity.
- Future research should focus on expanding data accumulation, diversifying datasets, and developing targeted ML models for broader BES deployment.
