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Operational parameters for packed beds in solid-state cultivation.

E Gumbira-Sa'id1, P F Greenfield, D A Mitchell

  • 1Inter University Centre of Biotechnology, Bogor Agricultural University, Bogor, Indonesia.

Biotechnology Advances
|January 1, 1993
PubMed
Summary
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Packed bed bioreactors for solid-state cultivation show promise. Researchers found that while pressure drop indicates fungal growth, it cannot be used for direct monitoring due to protein content changes.

Area of Science:

  • Biotechnology
  • Microbial Cultivation
  • Bioprocess Engineering

Background:

  • Packed bed cultivation systems offer potential for solid-state cultivation (SSC) but require further characterization.
  • Understanding factors influencing fungal growth in these systems is crucial for optimization.

Purpose of the Study:

  • To investigate the impact of particle size and substrate loading on Rhizopus oligosporus growth in packed bed bioreactors.
  • To evaluate pressure drop and protein content as indicators of fungal growth.

Main Methods:

  • Cultivations of Rhizopus oligosporus on sago-beads were conducted in large and small packed bed bioreactors.
  • Particle size and substrate loading were varied.
  • Differential pressure drop and protein content were monitored over time.

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Main Results:

  • Differential pressure drop peaked between 34 and 44 hours, then declined.
  • The highest pressure drop was observed with the smallest particle size and lowest substrate loadings.
  • Protein content continuously increased, indicating ongoing fungal growth.

Conclusions:

  • Pressure drop dynamics in packed bed bioreactors are influenced by particle size and substrate loading.
  • Pressure drop alone is insufficient for directly monitoring fungal growth in this system due to continued protein accumulation.